Pelitinib (EKB-569) ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

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SYN-1141-M001 SYN-1141-M005 SYN-1141-M010 SYN-1141-M050

102992-320EA 119.08 USD

102992-320 102992-322 102992-324 102992-326

Pelitinib (EKB-569) ≥95%

Pelitinib (EKB-569)

Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway.

Formula: C₂₄H₂₃ClFN₅O₂
MW: 467.92 g/mol
Storage Temperature: Freezer

MDL Number: MFCD09837868
CAS Number: 257933-82-7

Specification Test Results

Purity	95%
Appearance/Color	Solid.
Solubility	Soluble in DMSO or ethanol.

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