GSK690693 ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

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AG-CR1-3628-M005 AG-CR1-3628-M025

102987-440EA 131.54 USD

102987-440 102987-442

GSK690693 ≥95%

GSK690693

pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively. Inhibits AMPK, DAPK3, PAK4, 5 and 6, as well as members of the AGC kinase family including PKA, PrkX and PKC isoforms (IC50 100 nM). Occupies the ATP binding pocket of the kinase domain and competes with ATP. Anti-cancer compound both in vitro and in vivo. Blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner, which leads to antiproliferative and apoptotic effects in tumor cell lines. Induces hyperglycemia related to peripheral insulin resistance, increased gluconeogenesis, and/or hepatic glycogenolysis.

Formula: C₂₁H₂₇N₇O₃
MW: 425.5 g/mol
Storage Temperature: Freezer

MDL Number: MFCD14105605
CAS Number: 937174-76-0
UN: 2811
ADR: 6.1 III

Specification Test Results

Purity	95%
Appearance/Color	Off-white to pale yellow solid.
Solubility	Soluble in DMSO. Slightly soluble (1mg/ml) in ethanol.

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