4-Hydroxyphenylpyruvic Acid
Supplier: Van Der Voort Lucht en Milieu AmsteTotal Ratings: 0
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Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
Formula:
C₉H₈O₄ |
MDL Number:
MFCD00002591 CAS Number: 156-39-8 |
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