Dihydrorhodamine 123

Supplier: Van Der Voort Lucht en Milieu Amste

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102987-888EA 108 USD

102987-888 102987-890 102987-892

Dihydrorhodamine 123

Dihydrorhodamine 123

Cell-permeable non-fluorescent reactive oxygen species (ROS) indicator. Passively diffuses across membranes where it is oxidized by peroxynitrite to rhodamine 123 which localizes in the mitochondria and exhibits green fluorescence (Ex/Em wavelengths of 500 and 536 nm). Used to investigate reactive oxygen intermediates produced by human and murine phagocytes, activated rat mast cells and cultured endothelial cells. In addition, it has been used together with Fura Red calcium indicator to simultaneously measure oxidative bursts and Ca2+ fluxes in monocytes and granulocytes. Dihydrorhodamine 123 has been shown to be a more sensitive probe than H2DCFDA for detecting granulocyte respiratory bursts.

Formula: C₂₁H₁₈N₂O₃

MDL Number: MFCD04221428
CAS Number: 109244-58-8

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