Loxoribine

Supplier: Van Der Voort Lucht en Milieu Amste
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AG-CR1-3584-M005 AG-CR1-3584-M025
102988-650EA 41.54 USD
102988-650 102988-652
Loxoribine
Loxoribine

Guanosine analog derivatized at position N7 and C8. Very potent immunostimulatory compound that increases cytokine production. Antitumor and antiviral activity compound. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7). Co-incubation with thymidine homopolymer oligodeoxynucleotides (ODN) redirected the stimulatory effect of loxoribine away from TLR7 toward TLR8. Induces autophagy and autophagy-induced cell death in Caco-2 cells. Shows adjuvant activity to increase the effectiveness of vaccines.

Formula: C₁₃H₁₇N₅O₆
MW: 339.308 g/mol
MDL Number: MFCD00867591
CAS Number: 121288-39-9

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