Lovastatin

Supplier: Van Der Voort Lucht en Milieu Amste
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AG-CN2-0051-M005 AG-CN2-0051-M025
102987-850EA 27.69 USD
102987-850 102987-852
Lovastatin
Lovastatin

Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest).

Formula: C₂₄H₃₆O₅
MW: 404.55 g/mol
MDL Number: MFCD00072164
CAS Number: 75330-75-5

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