Anti-CD107a Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: H4A3]

Supplier: Southern Biotechnology
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9835-02 9835-02S
100246-516EA 291.62 USD
100246-516 103265-426
Anti-CD107a Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: H4A3]
Antibodies
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.

Type: Primary
Antigen: CD107a
Clonality: Monoclonal
Clone: H4A3
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Rhesus, African Green Monkey, Pigtail Macaque, Sooty Mangabey
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