Anti-KLRG1 Hamster Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: 2F1]

Supplier: Southern Biotechnology
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1807-09 1807-09L
100243-892EA 347.85 USD
100243-892 100243-894
Anti-KLRG1 Hamster Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: 2F1]
Antibodies
The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

Type: Primary
Antigen: KLRG1
Clonality: Monoclonal
Clone: 2F1
Conjugation: RPE (R-Phycoerythrin)
Epitope:
Host: Hamster
Isotype: IgG
Reactivity: Mouse, Human
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