Anti-CD5 Rat Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: 4H8E5]

Supplier: Southern Biotechnology

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1546-09 1546-09L

100243-160EA 241.92 USD

100243-160 100243-162

Anti-CD5 Rat Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: 4H8E5]

Antibodies

CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.

Type: Primary
Antigen: CD5
Clonality: Monoclonal
Clone: 4H8E5
Conjugation: RPE (R-Phycoerythrin)
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse

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