(R)-Roscovitine ≥98% (by NMR)

Supplier: Van Der Voort Lucht en Milieu Amste

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AG-CR1-0006-M001 AG-CR1-0006-M005 AG-CR1-0006-M050

102515-884EA 41.54 USD

102515-884 102515-886 102515-888

(R)-Roscovitine ≥98% (by NMR)

(R)-Roscovitine

Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.

Formula: C₁₉H₂₆N₆O
Storage Temperature: Freezer

MDL Number: MFCD02266401
CAS Number: 186692-46-6

Specification Test Results

Purity	98% (NMR)
Appearance/Color	White to off-white solid.
Solubility	Soluble in DMSO or 100% ethanol; only moderately soluble in water.

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