2-Morpholino-8-phenylchromone ≥98% (by TLC)

Supplier: SAFE AND SURE NEDERLAND B.V.

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BML-ST420-0005 BML-ST420-0025

89164-868EA 163.5 USD

89164-868 89164-870

2-Morpholino-8-phenylchromone ≥98% (by TLC)

2-Morpholino-8-phenylchromone

PI3 kinase inhibitor

Potent, cell permeable, inhibitor of PI(3)K (phosphoinositide 3-kinase) that acts on the ATP-binding site of the enzyme. Displays an IC50 of 1.4 µM and inhibits all isoforms equally in in vitro assays using purified PI 3-kinase. (p110alpha IC50=0.63µM)Inhibits Pim-1 kinase with IC50=4.0µM.Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50µM. Induces apoptosis in many cell types by blocking the PI3-K/Akt anti-apoptotic pathway. Useful tool for identifying cellular events which are regulated by the PI3-K/Akt axis. Sensitizes tumor cells to drug-induced apoptosis independent of its PI3K inhibitory activity. For a negative control see LY-303,511 (Prod. No. ALX-270-410).

Formula: C₁₉H₁₇NO₃
MW: 307.35 g/mol

MDL Number: MFCD00270881
CAS Number: 154447-36-6

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