N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)

Supplier: SAFE AND SURE NEDERLAND B.V.

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N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)

N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)

BML-SL105-0005 BML-SL105-0025

89164-572EA 102.46 USD

89164-572 89164-574

N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)

N,N-Dimethylsphingosine, D-erythro

Sphingosine kinase inhibitor

Potent and specific inhibitor of sphingosine kinase (IC50=5µM) which blocks conversion of sphingosine to sphingosine-1-phosphate (Prod. No. BML-SL140). Inhibitor of protein kinase C (PKC) which also stimulates Src-kinase. May affect expression of cell surface selectins, which in turn mediate leukocyte or tumor cell adhesion to endothelial cells and platelets. Induces apoptosis. Stereospecifically induces EGF receptor autophosphorylation producing EGF-like activity in vitro in the absence of EGF. Produced endogenously via ceramide catabolism. May be a target for neuropathic pain therapy.

Synthetic.

CAS Number: 119567-63-4

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