Troglitazone 98 TLC_ASSAY_METHOD

Supplier: SAFE AND SURE NEDERLAND B.V.
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BML-GR210-0005 BML-GR210-0025
89158-794EA 163.5 USD
89158-794 89158-796
Troglitazone 98 TLC_ASSAY_METHOD
Troglitazone

PPAR ligand


Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9 µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells.


Synthetic.

Formula: C₂₄H₂₇NO₅S
MW: 441.5 g/mol
MDL Number: MFCD00878416
CAS Number: 97322-87-7

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