1,9-Pyrazoloanthrone ≥98% (by TLC)

Supplier: SAFE AND SURE NEDERLAND B.V.

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BML-EI305-0010 BML-EI305-0050

89158-018EA 97.01 USD

89158-018 89158-020

1,9-Pyrazoloanthrone ≥98% (by TLC)

1,9-Pyrazoloanthrone

Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

Jnk inhibitor

Yellow to brown solid.

Soluble in DMSO or methanol.

Formula: C₁₄H₈N₂O
MW: 220.231 g/mol
Storage Temperature: Ambient

MDL Number: MFCD00022289
CAS Number: 129-56-6

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