BAY 11-7085 ≥99%

Supplier: SAFE AND SURE NEDERLAND B.V.
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BML-EI279-0010 BML-EI279-0050
89157-952EA 126.44 USD
89157-952 89157-954
BAY 11-7085 ≥99%
BAY 11-7085

NF-kappaB inhibitor


An irreversible inhibitor of cytokine-inducible IkappaBalpha phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFalpha-induced phosphorylation and degradation of IkappaBalpha without affecting constitutive phosphorylation. Inhibition of IkappaBalpha phosphorylation and degradation results in the inactivation of NF-kappaB and NF-kappaB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.

Formula: C₁₃H₁₅NO₂S
MW: 249.328 g/mol
MDL Number: MFCD01862602
CAS Number: 196309-76-9

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