Dexamethasone ≥99% (by TLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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BML-EI126-0001 BML-EI126-0005
89157-624EA 101.37 USD
89157-624 89157-626
Dexamethasone ≥99% (by TLC)
Dexamethasone

Glucocorticoid receptor ligand


Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Activates Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells in vivo and thus promotes tryptophan catabolism and thereby suppression of T cells.

Formula: C₂₂H₂₉FO₅
MW: 392.47 g/mol
MDL Number: MFCD00064136
CAS Number: 50-02-2

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Environmentally Preferable

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