Rapamycin ≥98% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.

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Rapamycin ≥98% (by HPLC)

Rapamycin ≥98% (by HPLC)

BML-A275-0005 BML-A275-0025

89156-364EA 163.5 USD

89156-364 76002-362

Rapamycin ≥98% (by HPLC)

Rapamycin

Macrocyclic-triene antibiotic possessing potent immunosuppressant activity

Off-white or yellow solid

It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70^s6k, p33^cdk2 and p34^cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.

Soluble in chloroform, DMSO (25 mg/mL) or methanol

Packaging: Shipping temperature: Ambient

Formula: C₅₁H₇₉NO₁₃
Storage Temperature: Freezer

MDL Number: MFCD00867594
CAS Number: 53123-88-9

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