Lipopolysaccharides (from E.coli) serotype R515 (Re), TLRgrade™

Supplier: SAFE AND SURE NEDERLAND B.V.

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581-007-L002 581-007-L001

89152-762EA 348.8 USD

89152-762 76002-300

Lipopolysaccharides (from E.coli) serotype R515 (Re), TLRgrade™

Lipopolysaccharides

TLR4 activator.

Rough (R)-form LPS isolated and purified from E. coli R515 (Re mutant) by a modification of the PCP extraction method, converted to the uniform sodium salt form.

Strong activator of Toll-like receptor (TLR) 4. Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required. Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.

Specification Test Results

Concentration	1 mg/ml
Formulation	Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water
Purity	Absence of detectable protein or DNA contaminants with agonistic TLR activity

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