Necrox-5™ methanesulfonate

Supplier: SAFE AND SURE NEDERLAND B.V.
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430-167-M001 430-167-M005
89151-300EA 173.31 USD
89151-300 89151-302
Necrox-5™ methanesulfonate
Necrox-5™ methanesulfonate

Necrosis inhibitor.


Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

Formula: C₂₅H₃₁N₃O₃S·2CH₄O₃S
CAS Number: 1383718-29-3

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