A77 1726 ≥98% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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430-096-M005 430-096-M025
89151-098EA 80.66 USD
89151-098 89151-100
A77 1726 ≥98% (by HPLC)
A77 1726

Dihydrorotate dehydrogenase inhibitor


Physiologically active metabolite of the immunosuppressive drug leflunomide (Prod. No. ALX-430-095). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-kappaB activation in a dose- and time-dependent manner. Also inhibits the activity of cyclooxygenase-2 (COX-2) in vitro and in vivo.

Formula: C₁₂H₉F₃N₂O₂
MDL Number: MFCD00910058
CAS Number: 108605-62-5

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