Staurosporine ≥98% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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380-014-C250 380-014-M001 380-014-M005
89149-816EA 163.5 USD
89149-816 89149-818 89149-820 76203-096
Staurosporine ≥98% (by HPLC)
Staurosporine

Apoptosis inducer


Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.


Isolated from Streptomyces staurosporeus.


Protein kinase inhibitor.

Formula: C₂₈H₂₆N₄O₃
MW: 466.541 g/mol
MDL Number: MFCD18252446
CAS Number: 62996-74-1

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