Staurosporine ≥98% (by HPLC)
Supplier: SAFE AND SURE NEDERLAND B.V.Total Ratings: 0
Avg. Ratings: 0.0 out of 5
Apoptosis inducer
Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.
Isolated from Streptomyces staurosporeus.
Protein kinase inhibitor.
Formula:
C₂₈H₂₆N₄O₃ MW: 466.541 g/mol |
MDL Number:
MFCD18252446 CAS Number: 62996-74-1 |
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