Curcumin (from Curcuma longa) ≥98% (by HPLC), high purity

Supplier: SAFE AND SURE NEDERLAND B.V.

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Curcumin (from Curcuma longa) ≥98% (by HPLC), high purity

Curcumin (from Curcuma longa) ≥98% (by HPLC), high purity

350-028-M010 350-028-M050 350-028-M250

89148-944EA 50.14 USD

89148-944 89148-946 89148-948

Curcumin (from Curcuma longa) ≥98% (by HPLC), high purity

Curcumin

Inhibitor of Lipoxygenase and COX

Dual inhibitor of 5-lipoxygenase (IC50=8µM) and cyclooxygenase (COX) (IC50=52µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells. Has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10µM), the COP9 signalosome kinase (IC50=10µM) and p300/CBP.

Formula: C₂₁H₂₀O₆

MDL Number: MFCD00008365
CAS Number: 458-37-7

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