ABT-888 ≥98% (by HPLC)
Supplier: SAFE AND SURE NEDERLAND B.V.Total Ratings: 0
Avg. Ratings: 0.0 out of 5
PARP inhibitor
Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.
Formula:
C₁₃H₁₈Cl₂N₄O |
MDL Number:
MFCD12407402 CAS Number: 912445-05-7 |
Learn more

About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...