Human;Mouse;Pig;Rat;Sheep PACAP-38 Trifluoroacetate
Supplier: Frontier Scientific
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4031157.0500
4031157.1000
H-8430.0200BAEA
353.77
USD
H-8430.0200BA
H-8430.0500BA
H-8430.1000BA
Human;Mouse;Pig;Rat;Sheep PACAP-38 Trifluoroacetate
Proteins and Peptides
Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
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