Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH₂ Trifluoroacetate

Supplier: Frontier Scientific

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4045499.0001 4045499.0005

H-6408.0001BAEA 370.39 USD

H-6408.0001BA H-6408.0005BA

Ac-Arg-Cys-Met-5-aminopentanoyl-Arg-Val-Tyr-5-aminopentanoyl-Cys-NH₂ Trifluoroacetate

Proteins and Peptides

Melanin-concentrating hormone (MCH), originally isolated from salmon pituitary glands, has also been found in the mammalian CNS. In lower vertebrates, salmon MCH alters pigmentation by inducing melanosome aggregation within melanocytes of teleost fish, whereas it causes melanosome dispersion in amphibians and reptiles. The biological role of MCH in higher vertebrates, however, is not yet fully understood, but it may function as a neuromodulator and hypophysiotropic agent in the secretion of α-MSH, ACTH, and GH.

Full competitive MCH-1 receptor antagonist devoid of agonist potency for the human MCH-1 receptor even at micromolar concentrations (Kb = 3.6 nM).

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