Rat Galanin-Like Peptide Trifluoroacetate

Supplier: Frontier Scientific

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4047028.0500 4047028.1000

H-6204.0500BAEA 1307.18 USD

H-6204.0500BA H-6204.1000BA

Rat Galanin-Like Peptide Trifluoroacetate

Proteins and Peptides

Galanin-like peptide (GALP), first isolated from the porcine hypothalamus and subsequently also identified in rats and humans, is a 60 amino acid neuropeptide that unlike galanin, has a non-amidated C-terminus. Its amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) fragment of galanin. In contrast to galanin which is relatively non-selective, receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2) and a lower affinity for the GALR1 receptor. Furthermore, it could be demonstrated that GALP stimulates food intake with a ten fold higher orexigenic activity than galanin and may also affect emotional state in the CNS.

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