Human;Mouse;Rat Orexin A Trifluoroacetate

Supplier: Frontier Scientific

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Total Ratings: 0
Avg. Ratings: 0.0 out of 5

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4028262.0500 4028262.1000 4028262.5000

H-4172.0500BAEA 717.88 USD

H-4172.0500BA H-4172.1000BA H-4172.5000BA

Human;Mouse;Rat Orexin A Trifluoroacetate

Proteins and Peptides

Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. H-4172 also corresponds to bovine, canine, ovine, and porcine orexin A.

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