Stichodactyla Helianthus Neurotoxin (ShK) Trifluoroacetate

Supplier: Frontier Scientific

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4031286.0100 4031286.0500 4031286.1000

H-2358.0100BAEA 354.74 USD

H-2358.0100BA H-2358.0500BA H-2358.1000BA

Stichodactyla Helianthus Neurotoxin (ShK) Trifluoroacetate

Proteins and Peptides

These monosubstituted analogs of ShK toxin, a class of K channel blocking peptide toxins derived from the sea anemone Stichodactyla helianthus, were prepared in order to identify functionally important residues. Hereby it has been shown that the location of Lys²² within a helical structure represents a unique difference between the interactive surfaces of the sea anemone and scorpion toxins.

ShK-toxin, originally isolated from the sea anemone Stichodactyla helianthus, has been found to inhibit the specific binding of dendrotoxin I to rat brain membranes. Due to its unique structure (it contains three intramolecular disulfide bridges) and high affinity for some potassium channels, ShK-toxin may become a useful molecular probe for investigating potassium channels.

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