Cyclo(-D-Trp-Tyr)

Supplier: Frontier Scientific

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4005514.0050 4005514.0250

G-1805.0050BAEA 370.39 USD

G-1805.0050BA G-1805.0250BA

Cyclo(-D-Trp-Tyr)

Proteins and Peptides

Also known as dioxopiperazines, piperazine-2,5-diones or DKPs. Diketopiperazines may occur as by-products during peptide synthesis or during the degradation of peptides. These cyclic dipeptides have been detected as taste-modulating compounds in food, they often show biological activity. DKPs are valuable chiral synthons, employed e.g. in Schöllkopf's versatile bislactim ether approach. They also have found use as catalysts for enantioselective synthesis, e.g. in the asymmetric Strecker reaction. See also the TRH metabolite cyclo(-His-Pro), G-1745, and cyclo(-Asp-Phe), G-1695, the major degradation product of aspartame.

Hsieh et al. tested peptide nanotubes obtained from cyclo-(D-Trp-Tyr) as oral gene delivery carriers in nude mice.

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