LEE011 ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste
Ratings: (No Reviews)

Total Ratings: 0
Avg. Ratings: out of 5

SYN-1213-M001 SYN-1213-M005 SYN-1213-M010 SYN-1213-M050 SYN-1213-M100
102992-820EA 74.77 USD
102992-820 102992-822 102992-824 102992-826 102992-828
LEE011 ≥95%
LEE011

Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Formula: C₂₃H₃₀N₈O
MW: 434.5 g/mol
Storage Temperature: Freezer
MDL Number: MFCD27976795
CAS Number: 1211441-98-3

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.


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