VWR International - Chemicals and Laboratory Scientific Supplies

Cell lysis buffer 4, (100 ml), Enzo Life Sciences

Description: 100 mL

Catalog Number: 95043-744

Supplier: Enzo Life Sciences

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Anti-ERBB2 Rabbit Polyclonal Antibody

Description: Host: Rabbit, Isotype: IgG

Catalog Number: 89155-690

Supplier: Enzo Life Sciences

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Anacardic acid ≥95% (by 1H-NMR)

Catalog Number: 89147-748

Supplier: Enzo Life Sciences

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BML-267

Description: PTP1B inhibitor

Catalog Number: 89161-802

Supplier: Enzo Life Sciences

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Anti-MAPT Rabbit Polyclonal Antibody

Description: Tau is the principal microtubule-associated protein located in axons in the nervous system where it participates in events including the elongation, stabilisation and bundling of microtubules. The tau family consists of six isoforms identified by the insertion of three or four partial repeats of 30-31 amino acids in the C-terminal region. Subcellular fractionation studies have revealed tau to be associated with the membrane fraction, as well as with the cytoskeletal fraction and there is some evidence that the N-terminal domain of tau may be responsible for membrane binding as well as interaction with other cellular components. Tau extracted from human fetal and neonatal brains is moderately phosphorylated with 5-9 phosphorylated serine/threonine residues per molecule. Normal adult human brain tau shows a marked reduction in phosphorylation, but in certain neurodegenerative diseases (tauopathies) tau becomes hyperphosphorylated (6-15 phosphates per tau molecule have been identified) and associates to form filamentous aggregates. In Alzheimer’s disease (AD) hyperphosphorylated tau polymerises to form a mixture of paired helical filaments (PHF) and straight filaments which accumulate and contribute to the formation of neurofibrillary tangles - one of the characteristic features of AD. It was reported in 1998 that tau could be tyrosine phosphorylated when co-transfected with the src-family protein tyrosine kinase fyn. In 2004 the same group, using phospho-specific antibodies, reported that fyn phosphorylated Tyr18 of brain tau at an early developmental stage in mice, but that tyrosine phosphorylated tau was undetectable in adult mice. However, they also showed that PHF preparations were reactive to the tau-pTyr18-specific antibodies, implicating a role for fyn – and possibly other tyrosine kinases - in the neurodegenerative process.

Catalog Number: 89165-028

Supplier: Enzo Life Sciences

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NBQX ≥98% (by HPLC)

Description: Water soluble, potent and selective AMPA/kainate receptor antagonist.

Catalog Number: 89152-438

Supplier: Enzo Life Sciences

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Bleomycin sulfate (mixture) ≥98% (by HPLC)

Description: Anti-tumor agent

Catalog Number: 89156-580

Supplier: Enzo Life Sciences

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Tricyclodecan-9-yl xanthogenate potassium salt ≥98% (by TLC)

Description: Selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC). Has been used to study the coupling of phosphatidylcholine-specific phospholipase C with sphingomyelinase. Shows antitumor and antiviral activity. Inhibits basement membrane collagen synthesis, which is the last step in the development of a new blood vessel. Inhibits induction of nitric oxide synthases (NOS). Induces apoptosis. It indirectly inhibits phorbol ester stimulated PLD activity.

Catalog Number: 89164-802

Supplier: Enzo Life Sciences

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