You Searched For: PROSCI INCORPORATED

Catalog Number: (76011-698)

Supplier: Prosci

Description: This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.

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Catalog Number: (10813-796)

Supplier: Prosci

Description: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.

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Catalog Number: (75788-836)

Supplier: Prosci

Description: Interleukin-1 alpha (IL1 alpha) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1 alpha and IL1 beta that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1 alpha is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1 alpha. IL1 alpha possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.

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Catalog Number: (89416-978)

Supplier: Prosci

Description: FKBP15 Antibody: FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

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Catalog Number: (10097-708)

Supplier: Prosci

Description: The MDC gene is one of several Cys-Cys (CC) cytokine genes which are clustered on the q arm of chromosome 16.

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Catalog Number: (76194-138)

Supplier: Prosci

Description: This mAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.

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Catalog Number: (10106-590)

Supplier: Prosci

Description: Vax1 is required for axon guidance and major tract formation in the developing forebrain. It may contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk.

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Catalog Number: (76012-210)

Supplier: Prosci

Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified.

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Catalog Number: (76010-176)

Supplier: Prosci

Description: For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100

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Catalog Number: (76011-454)

Supplier: Prosci

Description: RGS7 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).

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Catalog Number: (76012-302)

Supplier: Prosci

Description: The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium.

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Catalog Number: (76011-012)

Supplier: Prosci

Description: Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.

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Catalog Number: (89419-614)

Supplier: Prosci

Description: ATG5 peptide is used for blocking the activity of ATG5 antibody.

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Catalog Number: (10116-296)

Supplier: Prosci

Description: Polyclonal antibody MEFV Host: Goat Target Species: human immunogen: MEFV antibody was raised against a 13 amino acid synthetic peptide near the internal region of MEFV. Application: ELISA, WB, IHC

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Catalog Number: (10112-462)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species: Human, Mouse, Immunogen: ARPC3 antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of ARPC3, Application: ELISA, WB

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Catalog Number: (10112-800)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species: Human, Mouse, Immunogen: ORP7 antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of ORP7, Application: ELISA

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