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Description: CD74 Monoclonal antibody, Clone: CLIP/1133, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recombinant full-length human CD74 protein, Application: IF, Western, FC, Size: 500 uL
Catalog Number: 75907-344
Supplier: Biotium


Description: Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Catalog Number: 75916-230
Supplier: Biotium


Description: In Western blotting, this antibody reacts with two bands of ~MW of 210 kDa and 300 kDa, identified as two isoforms of Tenascin C. Specificity of this MAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linkedhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.
Catalog Number: 75975-978
Supplier: Biotium


Description: Mitochondrial Marker, Monoclonal antibody, Clone: MTC754, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: Semi-purified mitochondrial preparation, Application: Immunofluorescence, Immunohistology (formalin), Size: 500uL
Catalog Number: 75961-922
Supplier: Biotium


Description: CD38 Monoclonal antibody, Clone: AT2, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: purified, Immunogen: human T cell line CCRF-CEM, Synonyms: Acute Lymphoblastic Leukemia Cells Antigen, Application: IF, FC, Size: 500 uL
Catalog Number: 75895-144
Supplier: Biotium


Description: At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Catalog Number: 75889-882
Supplier: Biotium


Description: This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Catalog Number: 75952-360
Supplier: Biotium


Description: This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Catalog Number: 75978-302
Supplier: Biotium


Description: CD282 / TLR2 Monoclonal antibody, Clone: TLR2/221, Host: Mouse, Species reactivity: Human, Monkey, Dog, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: Recom human TLR2, Synonyms: CD282, Toll-like receptor 2 (TLR2), Application: IF, IHC, Size: 100uL
Catalog Number: 75891-894
Supplier: Biotium


Description: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.
Catalog Number: 75883-738
Supplier: Biotium


Description: Glypican-3 Monoclonal antibody, Clone: GPC3/863, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recom full-length human GPC3 protein, Synonyms: DGSX, GPC3, GTR2-2, Application: IF, IHC, Size: 100uL
Catalog Number: 75927-664
Supplier: Biotium


Description: Cytokeratin 8 Monoclonal antibody, Clone: B22.1, Host: Mouse, Species reactivity: Rabbit, Pig, Cow, Sheep, Human, Isotype: IgG, K, Conjugate: CF647, Immunogen: Cytoskeletal preparation, Synonyms: CYK8, CYKER, Cytokeratin Endo A, Application: IF, Size: 100uL
Catalog Number: 75922-684
Supplier: Biotium


Description: Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF.
Catalog Number: 75960-606
Supplier: Biotium


Description: Glypican-3 Monoclonal antibody, Clone: 1G12, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: A Recom fragment containing amino acids 511-580, Synonyms: DGSX, GPC3, GTR2-2, Application: IF, IHC, Size: 100uL
Catalog Number: 75926-954
Supplier: Biotium


Description: Myogenin, Monoclonal antibody, Clone: MGN185, Host: Mouse, Species reactivity: Pig, Dog, Cat, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF405S, Immunogen: Rat myogenin peptide (aa 73-94), recombinant fragment (aa30-224), Synonym:cb553, Size: 100uL
Catalog Number: 75964-986
Supplier: Biotium


Description: Llama anti-mouse CF™ dye conjugates are prepared by labeling affinity purified llama anti-mouse IgG (H+L) with a selection of CF™ dyes. CF™ dyes offer combined advantages in brightness, photostability, and specificity compared other fluorescent dyes. Far-red fluorescent CF™647 (Ex/Em 650/665 nm) is brighter than Cy®5 and an excellent alternative to Alexa Fluor® 647 for antibody conjugates.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific. Cy®5 is a registered trademark of GE Healthcare.
Catalog Number: 10001-944
Supplier: Biotium