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Description: Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This substrate is hydrolyzed rapidly by MMP-13, but slowly by MMP-1, 2, 3, 8, 9 and 12, Abs/Em = 494/521 nm.
Sequence:QXL™ 520-PLGLWArK(5-FAM)-NH2
MW:1789.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103003-238

Supplier: Anaspec Inc

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Description: This peptide is histone H3 amino acid residues 1 to 21. It is phosphorylated at Thr-11 with a C-terminal GG linker, followed by a biotinylated lysine. The modification of Thr-11 via phosphorylation is processed by a number of enzymes, including protein kinase C-related kinase 1 (PRK1) and Serine/threonine-protein kinase Chk1. This has many important functions, such as the establishment of a novel chromatin marker for transcriptional regulation, and the regulation of DNA-damage induced transcriptional repression. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:ARTKQTARKS-pT-GGKAPRKQLA-GGK(Biotin)-NH2
MW:2802.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103008-620

Supplier: Anaspec Inc

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Description: This peptide is the mutant form of the b-Amyloid peptide (1-40). The mutation within the coding region of the ß-Amyloid precursor protein (APP) results in substitution of glycine for alanine in this peptide. Presenile dementia is present in a pattern consistent in the family of British origin with the dominant inheritance of Flemish APP mutation. The impact of the point mutation A21G on b-Amyloid structure and dynamics varies from b-Amyloid (1-40) to b-Amyloid (1-42).
Sequence: DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
Molecular Weight: 4315.9 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Catalog Number: 103007-218

Supplier: Anaspec Inc

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Description: This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.
Sequence:GAHWQFNALTVRGGGS-K(Biotin)
MW:2012.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103009-026

Supplier: Anaspec Inc

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Description: This sequence is amino acids 1 to 21 fragment of the histone 4, acetylated at the N-terminus and biotinylated on the side chain of Lys. A GG spacer has been added on the C-terminus of Lys.
Sequence:Ac-SGRGKGGKGLGKGGAKRHRKV-GGK(Biotin)
MW:2602.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103007-396

Supplier: Anaspec Inc

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Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

Catalog Number: 103010-162

Supplier: Anaspec Inc

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Description: Beta-amyloid 1-55 is the the 672-726 fragment of APP.
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKK
Molecular Weight: 5982.1 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Catalog Number: 103007-612

Supplier: Anaspec Inc

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Description: This peptide, derived from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is essential for its death antagonist function.
Sequence:GQVGRQLAIIGDDINR
MW:1724.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103006-878

Supplier: Anaspec Inc

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Description: This hybrid peptide named colivelin was synthesized to potentiate the neuroprotective effect of humanin (HN). Colivelin is composed of Activity-Dependent Neurotrophic Factor (ADNF) C-terminally fused to AGA-(C8R) HNG17, a potent HN derivative. Colivelin completely suppresses cell death induced by overexpressed Familial Alzheimer's disease (FAD)-causative genes and beta-amyloid (1-43). Intraperitoneally administered colivelin suppresses memory impairment and might serve as a novel drug candidate for treatment of Alzheimer's disease.
Sequence:SALLRSIPAPAGASRLLLLTGEIDLP
MW:2645.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103007-098

Supplier: Anaspec Inc

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Description: Several mutations within the β-amyloid precursor gene cause early onset familial Alzheimer's disease, and were shown to promote Aβ aggregation. In the dutch mutant, Glu 22 is replaced with Gln, leading to rapid formation of neuroteoxic aggregates with higher proteolysis resistance.
Sequence: DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV
Molecular Weight: 4328.9 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Catalog Number: 103006-542

Supplier: Anaspec Inc

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Description: This amino acids 11 to 22 fragment of b-amyloid is capable of forming well-organized amyloid fibrils in vitro, similar to the pathogenic ones found in amyloidosis. Analysis of the structural properties of one monomer of b-amyloid (11-22) as well as of the aggregation mechanisms for four chains of b-amyloid (11-22) showed that the system assembles rapidly into a random globular state that evolves into three- and four-stranded antiparallel beta-sheets. The aggregation process is considerably accelerated by the presence of preformed dimers.
Sequence: EVHHQKLVFFAEDVG
Molecular Weight: 1755 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Catalog Number: 103007-538

Supplier: Anaspec Inc

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Description: 7-Hydroxycoumarin-3-carboxylic acid is one of the most popular blue fluorophores for labeling proteins and nucleic acids mostly through the in situ formation of its succinimidyl ester (81206). This coumarin is also increasingly used to label peptides, nucleotides and carbohydrates.

Catalog Number: 103010-890

Supplier: Anaspec Inc

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Description: Beta-Casomorphin-7 is a milk opioid peptide derived from fragment 60-66 of bovine beta-Casein. It strongly stimulates mucin secretion in the rat jejunum through a nervous pathway and mu-opioid receptor activation. The presence of the Tyr-Pro aromatic sequence makes the peptide selective for the mu receptor while the high contents of proline residues in the sequence makes the peptide resistant to degradation by gastrointestinal enzymes.
Sequence: YPFPGPI
MW: 789.9 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Catalog Number: 103006-232

Supplier: Anaspec Inc

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Description: This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.
Sequence:MASGVMVSDDVVKVFN
MW:1698 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103007-442

Supplier: Anaspec Inc

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Description: This GluR23Y peptide was used in ELISA cell-surface assay for the insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y prevented any insulin-induced reduction. The blockade of insulin action was observed when the GluR23Y peptide was delivered into neurons by fusing it to the membrane transduction domain of HIV-1.
Sequence:YKEGYNVYG
MW:1092.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: 103007-392

Supplier: Anaspec Inc

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Description: This is the scrambled beta-Amyloid peptide amino acids 25 to 35. Pairing this peptide with the native b-Amyloid 25 to 35 amino acids peptide has been used to recognize its structure and functions.
Sequence: MAKGINGISGL
Molecular Weight: 1060.3 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Catalog Number: 103007-120

Supplier: Anaspec Inc

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