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Catalog Number: (75841-330)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The MPC-11 monoclonal antibody is expressed by a cell line adapted from the Merwin Plasmacytoma-11, and has unknown specificity. The MPC-11 line was obtained by intraperitoneal implantation into a BALB/c Mouseof a Millipore diffusion chamber and is used as an Isotype Control for MouseIgG2b antibodies.

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Catalog Number: (75843-760)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.

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Catalog Number: (75841-886)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.

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Catalog Number: (75843-842)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.

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Catalog Number: (75841-548)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The N418 monoclonal antibody specifically reacts with the integrin αx chain of the mouse CD11c, which is expressed on dendritic cells, CD4-/CD8+ intestinal intraepithelial lymphocytes (IEL) and some activated T lymphocytes. Low levels of CD11c were detected on mouse splenic natural killer cells and on the monocyte/macrophage lineage cells.CD11c expression is upregulated on IEL and T lymphocytes after activation. It binds to CD54, fibrinogen and iC3b and influences the leukocyte adhesive interactions. The N418 antibody binds to CD11c on splenic dendritic cells of the mouse in the T-dependent areas. It also contributes to the binding of iC3b.

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Catalog Number: (75844-016)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II. The RPA-T4 antibody is capable of blocking HIV binding and inhibiting syncytium formation, by binding to the D1 domain of the CD4 antigen. The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.

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Catalog Number: (75844-040)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.

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Catalog Number: (75842-570)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The RB6-8C5 monoclonal antibody reacts with the mouse Ly-6G (also known as Gr-1). The Ly-6G protein is a myeloid differentiation antigen of 21-25 kDa, expressed in a regulated manner by the myeloid lineage in the bone marrow, where the level of antigen expression is correlated with the granulocyte maturation and differentiation. In the bone marrow, the antigen is not expressed by the erythroid cells. From the peripheric cells, RB6-8C5 binds with monocytes, neutrophils and eosinophils.As a marker for the mouse monocytes, macrophages and granulocytes, the RB6-8C5 antibody is usually combined with M1/70, a macrophage labeling antibody (Anti-CD11b), for phenotypic analysis.

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Catalog Number: (75842-374)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

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Catalog Number: (75844-304)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2).

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Catalog Number: (75842-534)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The GARP5 monoclonal antibody specifically reacts with human Glycoprotein A Repetitions Predominant (GARP, also known as LRRC32 or Garpin) molecule, a 80 kDa transmembrane glycoprotein expressed on the cell surface. GARP is expressed in activated Treg cells, placenta, pancreas, liver, skeletal muscle, heart, lung, and kidney, and it acts as a receptor for latent TGF-β, which down-regulates the Treg cells action. 

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Catalog Number: (75841-364)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The RB6-8C5 monoclonal antibody reacts with the mouse Ly-6G (also known as Gr-1). The Ly-6G protein is a myeloid differentiation antigen of 21-25 kDa, expressed in a regulated manner by the myeloid lineage in the bone marrow, where the level of antigen expression is correlated with the granulocyte maturation and differentiation. In the bone marrow, the antigen is not expressed by the erythroid cells. From the peripheric cells, RB6-8C5 binds with monocytes, neutrophils and eosinophils.As a marker for the mouse monocytes, macrophages and granulocytes, the RB6-8C5 antibody is usually combined with M1/70, a macrophage labeling antibody (Anti-CD11b), for phenotypic analysis.

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Catalog Number: (75844-320)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The HIT2 monoclonal antibody specifically bind to human CD38, a 45kda type II transmembrane glycoprotein. CD38 is expressed on activated T cells, plasma cells, monocytes, macrophages, dendritic cells, and thymocytes. CD38 displays cyclase and hydrolase enzymatic activity and is involved in lymphocyte adhesion, activation, and cell signaling. Its ligand is CD31.

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Catalog Number: (75843-384)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The C1.18.4 monoclonal antibody is used as an Isotype Control for MouseIgG2a antibodies. It has unknown specificity and occurred spontaneously in a C3H mouse.

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Catalog Number: (75842-802)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The M1/70 monoclonal antibody specifically reacts with the 170 kDa αM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.

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Catalog Number: (75841-938)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation.The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

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