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Supplier: PeproTech, Inc.

Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Rat sRANK Ligand is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).

Supplier: PeproTech, Inc.

Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Rat VEGF

Catalog Number: (10771-652)

Supplier: PeproTech, Inc.

Description: PeproTech's Human VEGF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human VEGF in a sandwich ELISA format.

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Catalog Number: (10771-662)

Supplier: PeproTech, Inc.

Description: PeproTech's Human TNF-α ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human TNF-α in a sandwich ELISA format.

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Catalog Number: (10771-684)

Supplier: PeproTech, Inc.

Description: PeproTech's Murine IL-2 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine IL-2 in a sandwich ELISA format.

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Catalog Number: (10771-682)

Supplier: PeproTech, Inc.

Description: PeproTech's Murine IFN-γ ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine IFN-γ in a sandwich ELISA format.

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Catalog Number: (10771-668)

Supplier: PeproTech, Inc.

Description: PeproTech's Human SCF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human SCF in a sandwich ELISA format.

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Catalog Number: (10771-680)

Supplier: PeproTech, Inc.

Description: PeproTech's Murine IL-12 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine IL-12 in a sandwich ELISA format.

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Catalog Number: (10771-666)

Supplier: PeproTech, Inc.

Description: PeproTech's Human MCP-1 (CCL2) ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human MCP-1 (CCL2) in a sandwich ELISA format.

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Supplier: PeproTech, Inc.

Description: Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, that helps maintain pluripotency and self renewal via a STAT3-independent pathway. Recombinant Human Nanog is a 34.7 kDa protein, which is synthesized as a 304 amino acid polypeptide lacking a signal sequence for secretion.

Supplier: PeproTech, Inc.

Description: Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, that helps maintain pluripotency and self renewal via a STAT3-independent pathway. The introduction of nanog, along with Sox2, Oct4, and Lin28, into primary human fibroblasts was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology and gene expression. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors into primary, as well as transformed, cells. Recombinant Human Nanog-TAT is a 36.1 kDa protein, which is synthesized as a 304 amino acid polypeptide plus a 13- residue C-terminal TAT peptide.

Supplier: PeproTech, Inc.

Description: Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

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Supplier: PeproTech, Inc.

Description: CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues, including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal “mucin-like stalk” sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog). Recombinant Murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.

Supplier: PeproTech, Inc.

Description: MIP-3α is a CC chemokine, expressed in the liver, lymph nodes, appendix, PBL and lungs that can signal through the CCR6 receptor. MIP-3α is chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells, and inhibits colony formation of bone marrow myeloid immature progenitors. Recombinant Murine MIP-3α (CCL20) is a 7.9 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Supplier: PeproTech, Inc.

Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Murine MDC (CCL22) is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Supplier: PeproTech, Inc.

Description: Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3, including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation). Eotaxin-2 contains the four conserved cysteine residues present in CC chemokines. Recombinant Human Eotaxin-2 (CCL24) is an 8.8 kDa protein containing 78 amino acid residues.