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Description: RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. RFX is a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.

Catalog Number: 10106-944

Supplier: Prosci

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Description: TOP2A, also named as TOP2, belongs to the type II topoisomerase family. Topoisomerase II makes double-strand breaks. TOP2 control the topological states of DNA by transient breakage and subsequent rejoining of DNA strands. The antibody is specific to the gene TOP2A.

Catalog Number: 10096-198

Supplier: Proteintech

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Description: Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.

Catalog Number: 10332-654

Supplier: Bioss

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Description: Human PADI2 (Peptidyl Arginine Deiminase Type II) ELISA Kit

Catalog Number: 77518-962

Supplier: AFG BIOSCIENCE LLC

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Description: These bags are ideal for packaging applications requiring ISO Class 5 (FED-STD-209E Class 100/M3.5) cleanroom conditions.

Catalog Number: 21915-046

Supplier: Fisher Container

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Description: Crystalline granules. Moisture sensitive. Fluorinating agent. Purity based on metal contaminates only. Shipped in fluoropolymer resin.

Catalog Number: AA39739-09

Supplier: Thermo Scientific Chemicals

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Description: Human Calcium/Calmodulin-Dependent Protein Kinase type II Subunit beta (CAMK2B) ELISA Kit

Catalog Number: 76711-978

Supplier: AFG BIOSCIENCE LLC

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Description: Water ASTM Type II, distilled

Catalog Number: 101419-284

Supplier: Aqua Solutions

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Description: These MCE series advanced user interface balances have fully customizable hardware, software, and connectivity including touch, scroll, swipe functionality with factory-installed essential weighing applications and diverse QApp packages for optional software extension.

Catalog Number: 76377-008

Supplier: Sartorius

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Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Catalog Number: 76078-382

Supplier: Bioss

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Description: Human Macrophage Scavenger Receptor Types I and II (MSR1) ELISA Kit

Catalog Number: 76706-784

Supplier: AFG BIOSCIENCE LLC

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Description: CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM]

Catalog Number: 89358-300

Supplier: Genetex

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Description: Anti-MCV-type II Chemokine-like Protein Goat Polyclonal Antibody (Biotin)

Catalog Number: 220014-341

Supplier: R&D Systems

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Description: MHC II (HLA-DRA), Monoclonal antibody, Clone: 19-26.1, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgM, kappa, Conjugate: purified, Immunogen: Spleen cells of a patient with hairy cell leukemia (Daudi cells), Application: Immunofluorescence, Size: 100uL

Catalog Number: 75961-130

Supplier: Biotium

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Description: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Catalog Number: 10480-054

Supplier: Bioss

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Description: Potent and effective inhibitor of Golgi processing mannosidase II.

Catalog Number: 89162-576

Supplier: Enzo Life Sciences

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