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Catalog Number: (10782-512)
Supplier: Biosensis
Description: TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer.


Catalog Number: (76264-598)
Supplier: Biosensis
Description: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (Reference: uniprot.org). This antibody reacts with human and rat. Predicted to cross-react with horse, mouse, cow, pig and chicken.


Catalog Number: (10782-922)
Supplier: Biosensis
Description: Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament medium runs on SDS-PAGE gels in the range 145-170 kDa, with some variation in different species.


Catalog Number: (76545-488)
Supplier: Biosensis
Description: STAIN HQ-O RTD AMYLOID PLAQUE 40ML


Catalog Number: (76545-450)
Supplier: Biosensis
Description: KIT ELISA HUMAN MATURE NGF/PRONGF COMBO


Catalog Number: (76545-434)
Supplier: Biosensis
Description: KIT ELISA BOVINE A1 BETA CASEIN


Catalog Number: (76545-452)
Supplier: Biosensis
Description: KIT ELISA MOUSE MATURE NGF/PRONGF COMBO


Catalog Number: (76545-436)
Supplier: Biosensis
Description: KIT ELISA BOVINE A1 BETA CASEIN


Catalog Number: (76545-442)
Supplier: Biosensis
Description: KIT ELISA BOVINE A2 BETA CASEIN


Catalog Number: (76545-444)
Supplier: Biosensis
Description: KIT ELISA BOVINE A2 BETA CASEIN


Catalog Number: (76545-454)
Supplier: Biosensis
Description: KIT ELISA RAT MATURE NGF/PRONGF COMBO


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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