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Catalog Number: (10782-440)
Supplier: Biosensis
Description: The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. It is expressed exclusively in the nervous system and mainly upregulated at the early postnatal stage during mouse brain development. Employing Northern blot analysis Kamei et al found that amongst different regions of the adult human nervous system cerebellum expressed highest level of NB-3 mRNA. The expression of NB-3 in the cerebellum increases until adulthood. In contrast, the expression in the cerebrum declines to a low level after postnatal day 7. NB-3 like other neural recognition molecules plays a vitally important role in axonal guidance during development, plasticity, and maintenance of synaptic connections in the adult brain. Cui et al recently showed that NB-3 acts as a novel Notch ligand to participate in oligodendrocyte generation. Furthermore, NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Hence, the NB-3/Notch signaling pathway may be worthwhile a closer examination for its potential for the treatment of demyelinating diseases. Human NB-3 shares with rat NB-3 86% identity in nucleotide sequences and 90% identity in amino acid sequences. FUNCTION: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. SUBCELLULAR LOCATION: Cell membrane; lipid-anchor; GPI-anchor. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Purkinje cells of the cerebellum. DEVELOPMENTAL STAGE: Highly expressed after birth, reaching a maximum at the postnatal day 7, and declines thereafter in the cerebrum, whereas it increases in the cerebellum to adulthood.


Catalog Number: (76333-952)
Supplier: Biosensis
Description: Calbindin antibody, Host: Chicken, Reacts with human, cow, rat, mouse, Purity: IgY fraction, Antigen: Full-length recombinant human protein, Synonyms: Calbindin D28; D-28K, Applications: WB, ICC, IHC, Storage : Sto


Catalog Number: (76334-028)
Supplier: Biosensis
Description: NGFR/p75NTR Monoclonal antibody, Clone: 8J2, Host: Mouse, Reacts with human, mouse, rat, Isotype: IgG2a, Conjugate: FITC, Immunogen: Recombinant extracellular domain (aa 29-250) of human NGFR/p75NTR protein with N-t


Catalog Number: (78026-520)
Supplier: Biosensis
Description: FLUORESCENT STAIN GREEN NISSLFLUOR 40ML

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Catalog Number: (78026-512)
Supplier: Biosensis
Description: ELISA KIT IL1-RA HUMAN RAPID 1P

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Catalog Number: (78026-530)
Supplier: Biosensis
Description: LIPID STAIN LIPOFLUORER2 1000X 550UL PK4

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Catalog Number: (78026-519)
Supplier: Biosensis
Description: FLUORESCENT STAIN ORANGE NISSLFLUOR 40ML

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Catalog Number: (78026-536)
Supplier: Biosensis
Description: STAIN FLUOR NISSL NISSLFLUOR 10ML PK4

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Catalog Number: (76545-450)
Supplier: Biosensis
Description: KIT ELISA HUMAN MATURE NGF/PRONGF COMBO


Catalog Number: (76545-434)
Supplier: Biosensis
Description: KIT ELISA BOVINE A1 BETA CASEIN


Catalog Number: (78026-522)
Supplier: Biosensis
Description: LIPID STAIN LIPOFLUOR-P1 1000X 550UL PK4

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Catalog Number: (78026-534)
Supplier: Biosensis
Description: LIPID STAIN LIPOFLRDMNDT 1000X 550UL PK4

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Catalog Number: (78026-513)
Supplier: Biosensis
Description: ELISA KIT IL1-RA HUMAN RAPID 2P

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Catalog Number: (78026-518)
Supplier: Biosensis
Description: FLUORESCENT STAIN RED NISSLFLUOR 40ML

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Catalog Number: (78026-524)
Supplier: Biosensis
Description: LIPID STAIN LIPOFLUORER1 1000X 550UL PK4

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Catalog Number: (78026-532)
Supplier: Biosensis
Description: LIPID STAIN LIPOFLRDMNLD 1000X 550UL PK4

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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