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Catalog Number: (10782-870)
Supplier: Biosensis
Description: The enzyme Peptidylprolyl isomerase (Pin1) is responsible for flipping the proline ring from the cis to trans conformation. This enzyme regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity (ref: SWISSPROT). Pin1 is concentrated in the nucleus in small punctate structures and is particularly obvious in tumor cells.


Catalog Number: (76333-986)
Supplier: Biosensis
Description: Neurotrophin Antibody Kit (Trial Size) contains 500 ug each of popular sheep antibodies raised against BDNF, NGF, NT3 and NT4/5, and a negative control sheep IgG, to investigate neurotrophin protein expression and


Catalog Number: (10781-986)
Supplier: Biosensis
Description: FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.


Catalog Number: (10782-628)
Supplier: Biosensis
Description: CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.


Catalog Number: (76334-004)
Supplier: Biosensis
Description: Heat Shock Protein 27 Monoclonal antibody, Clone: 6H11, Host: mouse, Reactivity: Human, Isotype: IgG1, Specificity: reacts with a 27 kDa band on a crude extract from HeLa cells, Applications: WB, ICC, Flow, Form:


Catalog Number: (10782-638)
Supplier: Biosensis
Description: NULL


Catalog Number: (10782-062)
Supplier: Biosensis
Description: Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. GAPDH may have other roles in the activation of transcription and in the regulation of apoptosis as well as Alzheimer's disease and Huntington's disease. The immunogen used to raise this particular antibody was extensively purified pig GAPDH. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue.


Catalog Number: (10782-020)
Supplier: Biosensis
Description: Neuropeptide VF is the precursor of neuropeptides NPSF (RFRP-1), RFRP-2 and RFRP-3 (NPVF). RFRP-3 is reported to inhibit forskolin-induced production of cAMP. RFRP-3 has also been shown to block morphine-induced analgesia.


Catalog Number: (10782-702)
Supplier: Biosensis
Description: TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). PTM: N-glycosylated. PTM: Phosphorylated by PKA. SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.


Catalog Number: (10782-476)
Supplier: Biosensis
Description: ATG10 plays a role in autophagy. It is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conjugations and modificatioon of a soluble form of MAPLC3 1A, a homolog of yeast ATG8, to a membrane bound form.  It is also able to directly interact either with ATG5 or ATG7.


Catalog Number: (76334-048)
Supplier: Biosensis
Description: IBA1 antibody, Host: Rabbit, Reacts with human, rat, mouse, Purity: whole serum, Antigen: C-terminal peptide of human IBA1 protein coupled to KLH, Applications: WB, ICC, Storage: Store lyophilised antibody at 2-8C,


Catalog Number: (10782-592)
Supplier: Biosensis
Description: NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.


Catalog Number: (76333-990)
Supplier: Biosensis
Description: Actin Monoclonal antibody, Clone: 5J11, Host: mouse, Reactivity: Human, rat, Isotype: IgG1, Immunogen: Actin prepared from bovine brain, Applications: WB, ICC, FLOW, Form: Lyophilized from PBS. Contains 5% trehalos


Catalog Number: (10782-610)
Supplier: Biosensis
Description: The beta Amyloid peptide is derived from the cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. Beta amyloid peptides are the major constituents of the plaques and tangles that occur in Alzheimer's disease.


Catalog Number: (10782-540)
Supplier: Biosensis
Description: Clathrin is a major protein component of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice to either the plasma membrane or the trans-Golgi network. These specialised organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Clathrin localises to the cytoplasmic face of coated pit and vesicle membranes.


Catalog Number: (76334-022)
Supplier: Biosensis
Description: Parvalbumin Monoclonal antibody, Clone: 3C9, Host: Mouse, Reacts with human, mouse, rat, Isotype: IgG1, Immunogen: Full-length recombinant human protein, Purity: Affinity purified, Store lyophilised antibody at 2-8C


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