You Searched For: PROSCI INCORPORATED

Catalog Number: (10111-068)

Supplier: Prosci

Description: AKT1 is a general protein kinase capable of phosphorylating several known proteins.The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.

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Catalog Number: (76749-122)

Supplier: Prosci

Description: Anti-HERC3 Rabbit Polyclonal Antibody

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Catalog Number: (77126-810)

Supplier: Prosci

Description: ATP5F1 Peptide

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Catalog Number: (76755-586)

Supplier: Prosci

Description: Anti-IKBKE Rabbit Polyclonal Antibody

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Catalog Number: (76756-986)

Supplier: Prosci

Description: Anti-ODC1 Rabbit Polyclonal Antibody

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Catalog Number: (10111-268)

Supplier: Prosci

Description: DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia

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Catalog Number: (76750-866)

Supplier: Prosci

Description: Anti-EZH2 Rabbit Polyclonal Antibody

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Catalog Number: (10099-934)

Supplier: Prosci

Description: IFNGR2 is the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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Catalog Number: (76751-010)

Supplier: Prosci

Description: Anti-MRPL41 Rabbit Polyclonal Antibody

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Catalog Number: (10110-492)

Supplier: Prosci

Description: Toll-like receptors (TLRs) and IL1R (IL1R1) are part of the innate immune response aimed at mobilizing defense mechanisms in response in infection or injury. Pellino proteins, such as PELI3, are intermediate components in the signaling cascades initiated by TLRs and IL1R.Toll-like receptors (TLRs; see MIM 603030) and IL1R (IL1R1; MIM 147810) are part of the innate immune response aimed at mobilizing defense mechanisms in response in infection or injury. Pellino proteins, such as PELI3, are intermediate components in the signaling cascades initiated by TLRs and IL1R (Jensen and Whitehead, 2003 [PubMed 12874243]).

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Catalog Number: (76630-396)

Supplier: Prosci

Description: Anti-SPN Recombinant Antibody [Clone: 84-3C1]

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Catalog Number: (10765-954)

Supplier: Prosci

Description: Rat Monoclonal MHC Class II Antibody [M5/114.15.2] (APC), Isotype: IgG2b, kappa, Species: Mouse, Application: FACS

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Catalog Number: (10107-756)

Supplier: Prosci

Description: MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

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Catalog Number: (10114-642)

Supplier: Prosci

Description: Polyclonal, Host: Goat; Target Species: Mouse; Immunogen: POU5F1 antibody was raised against a 13 amino acid synthetic peptide near the internal region of POU5F1 (mouse); Applications: ELISA,Western blotting

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Catalog Number: (10116-918)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: ZNF703 antibody was raised against a 14 amino acid synthetic peptide near the internal region of ZNF703; Application: ELISA, Western Blot

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Catalog Number: (76749-938)

Supplier: Prosci

Description: Anti-TSR-033 Recombinant Antibody

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