You Searched For: PROSCI INCORPORATED

Catalog Number: (10097-620)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit, Species reacivity: Mouse, Immunogen: Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant msRANKL (murine sRANK Ligand), Tested application: ELISA, WB

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Catalog Number: (89415-928)

Supplier: Prosci

Description: PIST Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6. Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1.

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Catalog Number: (89415-364)

Supplier: Prosci

Description: Bonzo Antibody: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 serves as coreceptor for SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.

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Catalog Number: (10070-440)

Supplier: Prosci

Description: Plays an important role in the physiology of adrenergic neurons.

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Catalog Number: (89420-408)

Supplier: Prosci

Description: RHBDD3 peptide is used for blocking the activity of RHBDD3 antibody.

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Catalog Number: (10749-250)

Supplier: Prosci

Description: ICAD Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which is cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death.

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Catalog Number: (10113-224)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: ARG1 antibody was raised against a 15 amino acid synthetic peptide near the C-Terminus of ARG1, Tested Applications: ELISA, WB

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Catalog Number: (10115-000)

Supplier: Prosci

Description: Polyclonal, Host: Goat; Target Species: Human; Immunogen: CBARA1 antibody was raised against a 14 amino acid synthetic peptide near the internal region of CBARA1 (aa 113-126); Applications: ELISA,Western blotting

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Catalog Number: (77121-216)

Supplier: Prosci

Description: Cryopyrin Peptide

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Catalog Number: (75794-294)

Supplier: Prosci

Description: Human B7-H2 is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2 and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

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Catalog Number: (75791-802)

Supplier: Prosci

Description: Human Follicle-stimulating hormone (FSH) is a member of glycoprotein hormones subunit beta family, whichalso includes LH, chorionic gonadotropin (CG) and thyroid-stimulating hormone (TSH). FSH and its familymembers are heterodimers consisting of non-covalently linked alpha- and beta -subunits. They share an identical alphasubunit, and beta -subunits vary. FSH has a unique beta -subunit (FSH beta ), which confers its specific biologic activityand is responsible for interaction with the FSH-receptor which belongs to a subfamily of GPCRs calledleucine-rich-repeat-containing GPCRs (LGRs). FSH is secreted from the pituitary gland and regulatesreproduction in mammals. FSH stimulates sertoli cell proliferation in testes and supports spermatogenesis inmales, and induces the maturation of ovarian follicles in females.

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Catalog Number: (76753-212)

Supplier: Prosci

Description: Anti-NEK8 Rabbit Polyclonal Antibody

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Catalog Number: (10105-944)

Supplier: Prosci

Description: HEXIM1 expression is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. The function of this protein is not yet known.

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Catalog Number: (10751-574)

Supplier: Prosci

Description: SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

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Catalog Number: (75791-670)

Supplier: Prosci

Description: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

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Catalog Number: (76753-184)

Supplier: Prosci

Description: Anti-ADIPOR2 Rabbit Polyclonal Antibody

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