You Searched For: PROSCI INCORPORATED

Catalog Number: (10110-852)

Supplier: Prosci

Description: IL13RA2 is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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Catalog Number: (10070-582)

Supplier: Prosci

Description: GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, which is located on chromosome 11q13 , is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

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Catalog Number: (10116-768)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: SNX5 antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of SNX5; Application: ELISA, Western Blot, IHC

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Catalog Number: (10765-870)

Supplier: Prosci

Description: The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

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Catalog Number: (10069-420)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit, Species Reactivity: Virus, Immunogen: Strain F (human), Tested Applications: Western blotting

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Catalog Number: (89416-460)

Supplier: Prosci

Description: ATG5 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells.

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Catalog Number: (10766-494)

Supplier: Prosci

Description: The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8 alpha is a member of the Ig superfamily, expressed as a homodimer (CD8 alpha alpha) or as a heterodimer (CD8 alpha beta). CD8+ alpha beta T lymphocytes express both CD8 alpha alpha and CD8 alpha beta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

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Catalog Number: (10071-482)

Supplier: Prosci

Description: p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes

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Catalog Number: (10071-104)

Supplier: Prosci

Description: Haptoglobin, Mixed type. Haptoglobin combines with free plasma hemoglobin, prevent loss of iron through the kidneys and protect the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.

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Catalog Number: (10764-420)

Supplier: Prosci

Description: The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II. The RPA-T4 antibody is capable of blocking HIV binding and inhibiting syncytium formation, by binding to the D1 domain of the CD4 antigen. The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.

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Catalog Number: (10097-662)

Supplier: Prosci

Description: Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia.

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Catalog Number: (10114-364)

Supplier: Prosci

Description: Polyclonal, Host: Goat; Target Species: Rat; Immunogen: Alk antibody was raised against a 13 amino acid synthetic peptide near the internal region of Alk (mouse); Applications: ELISA,Western blotting

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Catalog Number: (10116-894)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: WT1 antibody was raised against a 15 amino acid synthetic peptide near the N-Terminus of WT1; Application: ELISA, Western Blot

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Catalog Number: (10113-304)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: G6PD antibody was raised against a 15 amino acid synthetic peptide near the internal region of G6PD (aa 308-320), Tested Applications: ELISA, WB

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Catalog Number: (10080-332)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit, Species Reactivity: Human, Immunogen: Synthetic peptide containing a sequence corresponding to a region within amino acids 585 and 648 of Human FOXN1, Tested Applications: IHC, WB

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Catalog Number: (75790-894)

Supplier: Prosci

Description: Chloride Intracellular Channel Protein 1 (CLIC1) belongs to the Chloride Channel CLIC family and contains one GST C-terminal domain. CLIC1 can be expressed in various cell types, but it is especially prominent in the heart, placenta, liver, kidney, and pancreas. CLIC1 can insert into membranes and form chloride ion channels. The channel activity depends on the pH. CLIC1 membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. CLIC1 is also involved in the regulation of the cell cycle.

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