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Description: IFNA7 belongs to the alpha/beta interferon family. IFNA7 is produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Catalog Number: 10104-330
Supplier: Prosci


Description: PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).
Catalog Number: 76009-236
Supplier: Prosci


Description: KappaB ras1 Antibody: KappaB ras-1 (kappa B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa B (Ikappa B), an inhibitor of the transcription factor NF-kappa B. Ikappa B exists in two homologous forms, Ikappa B-alpha and Ikappa B-beta, although Ikappa B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa B-alpha-NF-kappa B complexes can shuttle in and out of the nucleus, Ikappa B-beta-NF-kappa B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa B-beta and regulating the rate of degradation of Ikappa B-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.
Catalog Number: 10749-472
Supplier: Prosci


Description: CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells (Niimi et al., 2001 [PubMed 11585919]).
Catalog Number: 10111-518
Supplier: Prosci


Description: Anti-Mouse Monoclonal Antibody [clone: [SB58c]]
Catalog Number: 77133-074
Supplier: Prosci


Description: CLDN8, clustered with CLDN17 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X (17-22)-W-X (2)-C-X (8-10)-C.
Catalog Number: 10105-678
Supplier: Prosci


Description: For WB starting dilution is: 1:1000
Catalog Number: 76011-562
Supplier: Prosci


Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: MDFI antibody was raised against a 15 amino acid synthetic peptide near the internal region of MDFI, Tested Applications: ELISA, WB
Catalog Number: 10113-732
Supplier: Prosci


Description: IBRDC3 is a cytolysis-associated transmembrane protein expressed in natural killer (NK) cells and T lymphocytes following cytokine stimulation (Kozlowski et al., 1999 [PubMed 10438909]).
Catalog Number: 76010-266
Supplier: Prosci


Description: For WB starting dilution is: 1:1000
Catalog Number: 76009-554
Supplier: Prosci


Description: For WB starting dilution is: 1:1000
Catalog Number: 76010-432
Supplier: Prosci


Description: Polyclonal antibody CDKN1B Host: Goatimmunogen: CDKN1B antibody was raised against a 14 amino acid synthetic peptide near the C-Terminus of CDKN1B. Application: ELISA, WB
Catalog Number: 10115-352
Supplier: Prosci


Description: The 4S.B3 is a neutralizing antibody that binds with the human Interferon-gamma (IFN-gamma) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-alpha, to inhibit proliferation of normal and transformed cells. IFN- gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-gamma is not affected by glycosylation
Catalog Number: 10765-290
Supplier: Prosci


Description: Skin tissue lysate (human) was prepared by homogenization in lysis buffer (10 mM HEPES pH7.9, 1.5 mM MgCl<sub>2</sub>, 10 mM KCl, 1 mM ethylenediaminetetraacetic acid, 10% glycerol, 1% NP-40, and a cocktail of protease inhibitors)
Catalog Number: 10062-204
Supplier: Prosci


Description: The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3 epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
Catalog Number: 10766-306
Supplier: Prosci


Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
Catalog Number: 76010-300
Supplier: Prosci


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