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Catalog Number: (75789-350)
Supplier: Prosci
Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.


Catalog Number: (10098-170)
Supplier: Prosci
Description: Interferon-gamma-inducible 10 kD protein (IP-10), is a CXC chemokine with chemoattractant properties for CD4-positive T cells and inhibits early normal and leukemic hemopoietic progenitor proliferation. IP-10 is produced by a wide variety of cell types ranging from neutrophils and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV encephalitis, cutaneous T cell lymphoma, chronic hepatitis and acute anterior uveitis. Various observations strongly suggest a role for the CXC chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis.


Catalog Number: (10764-498)
Supplier: Prosci
Description: The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.


Catalog Number: (75792-892)
Supplier: Prosci
Description: Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.


Catalog Number: (10751-408)
Supplier: Prosci
Description: UHRF1BP1L Antibody: The Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1-like (UHRF1BP1L) is closely related to UHRF1BP1, also known as ICBP90, a transcription and cell cycle regulator that specifically binds to the histone H3 N-terminal tail. While little is known of UHRF1BP1L, UHRF1BP1 is required for proper heterochromatin formation in mammalian cells. Furthermore, UHRF1BP1 is thought to be a pivotal target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells, suggesting that UHRF1BP1L may also be involved in chromatin regulation and cell proliferation.


Catalog Number: (76009-448)
Supplier: Prosci
Description: ENSA belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.


Catalog Number: (10115-336)
Supplier: Prosci
Description: Polyclonal antibody BIRC7 Host: Goat Target Species: human immunogen: BIRC7 antibody was raised against a 13 amino acid synthetic peptide near the C-Terminus of BIRC7 Application: ELISA, WB


Catalog Number: (76010-246)
Supplier: Prosci
Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).


Catalog Number: (10113-590)
Supplier: Prosci
Description: Polyclonal, Host: Goat, Species Reactivity: Mouse, Rat, Immunogen: CIRBP antibody was raised against a 12 amino acid synthetic peptide near the C-Terminus of CIRBP (aa 161-172, Tested Applications: ELISA, WB


Catalog Number: (76764-214)
Supplier: Prosci
Description: Anti-CHEK2 Rabbit Polyclonal Antibody


Catalog Number: (76752-914)
Supplier: Prosci
Description: Anti-BTD Rabbit Polyclonal Antibody


Catalog Number: (77120-802)
Supplier: Prosci
Description: Influenza A H3N2 Recombinant Influenza A (H3N2) Antigen (from Embryonated chicken eggs)


Catalog Number: (77130-728)
Supplier: Prosci
Description: Mouse Recombinant TIM-3 Protein (from HEK293 Cells)


Catalog Number: (77121-240)
Supplier: Prosci
Description: Anti-LAG3 Mouse Monoclonal Antibody [clone: 2G8]


Catalog Number: (89419-618)
Supplier: Prosci
Description: RIM2 peptide is used for blocking the activity of RIM2 antibody.


Catalog Number: (76751-776)
Supplier: Prosci
Description: Anti-IFNLR1 Rabbit Polyclonal Antibody


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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