You Searched For: PROSCI INCORPORATED

Catalog Number: (77131-744)

Supplier: Prosci

Description: Anti-AIFM1 Goat Polyclonal Antibody

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Catalog Number: (77128-402)

Supplier: Prosci

Description: Anti-PTPRC Mouse Monoclonal Antibody [clone: [F8-11-13]] (PE (Phycoerythrin)-Cy5®)

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Catalog Number: (77124-986)

Supplier: Prosci

Description: Anti-Mouse Monoclonal Antibody [clone: [TCR-1]] (Biotinylated)

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Catalog Number: (10749-714)

Supplier: Prosci

Description: IRAK2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues.

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Catalog Number: (10068-292)

Supplier: Prosci

Description: Monoclonal, Host: Mouse, Clone: [CE2.10], Species Reactivity: Mouse, Human, Isotype: Mouse IgG2a, Immunogen: Perforin (monoclonal CE2.10) antibody was raised against recombinant mouse perforin (aa. 98-534), Tested Applications: Western blotting, IP

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Catalog Number: (10080-786)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit, Species reacivity: human, Immunogen: Internal domain of human, Tested application: IHC

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Catalog Number: (10113-874)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: GM2A antibody was raised against a 12 amino acid synthetic peptide near the internal region of GM2A (aa 164-175), Tested Applications: ELISA, WB

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Catalog Number: (10070-770)

Supplier: Prosci

Description: Monoclonal antibody RANKL Host: Rat Clone no: Ranky-1 Species reactivity: human isotype: IgG1 immunogen: RANKL antibody was raised against recombinant human soluble RANKL extracellular domain (aa 151-316). Tested application: ELISA, WB, IHC

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Catalog Number: (10113-202)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: AIF1 antibody was raised against an 11 amino acid synthetic peptide near the C-Terminus of AIF1, Tested Applications: ELISA, WB, IHC

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Catalog Number: (10110-350)

Supplier: Prosci

Description: The exact function ofLOC401898 remains unknown.

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Catalog Number: (10069-654)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit, Species Reactivity: Bacteria, Immunogen: Purified Choleragenoid, Tested Applications: Western blotting

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Catalog Number: (10748-974)

Supplier: Prosci

Description: Ninjurin-1 (NINJ1) is a homophilic adhesion molecule that is strongly induced in dorsal root ganglion (DRG) and Schwann cells following nerve injury and promotes neurite outgrowth of DRG neurons , suggesting that NINJ1 may play a role in nerve regeneration. NINJ1 is transcriptionally regulated by p53 and is induced by DNA damage in a p53-dependent manner. A deficiency of NINJ1 increases p53 expression, suppresses cell proliferation, but enhances apoptosis and premature senescence in a p53-dependent manner as well as radiation-induced cell mortality.

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Catalog Number: (89420-516)

Supplier: Prosci

Description: MYBPC2 peptide is used for blocking the activity of MYBPC2 antibody.

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Catalog Number: (75789-484)

Supplier: Prosci

Description: Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is a member of the Carcinoembryonic Antigen (CEA) family, which belongs to the immunoglobulin superfamily. CEACAM1 is originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it is found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM1 mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. In addition, CEACAM1 plays a important role in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.

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Catalog Number: (10750-808)

Supplier: Prosci

Description: CALHM1 Antibody: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

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Catalog Number: (10748-600)

Supplier: Prosci

Description: Pst1 Antibody: Protoplast secreted protein 1 (Pst1) is an anchored plasma membrane protein. Pst1 was previously identified as a protein secreted by yeast regenerating protoplasts, which suggests a role in cell wall construction. Pst1 is a protein with 444 amino acids and is attached to yeast cell wall via a glycosylphosphatidylinisotol (GPI) anchor. Pst1 contains 15 potential N-linked glycosylation sites and is heavily glycosylated. It migrates at approximately 200 kDa on SDS-PAGE when produced in wild type S. cerevisiae. Our Pst1 protein (Catalog No. 95-151) was expressed in a genetically manipulated triple-mutant (TM) S. cerevisiae stain, which results in the production of sole Man8GlcNAc2 carbohydrate structures and Pst1 migration at approximately 100 kDa. When produced in the TM yeast, Pst1 can be recognized by several glycan-specific HIV-1 broadly neutralizing antibodies, including 2G12 and recently identified PGT antibodies. Among several heavily N-glycosylated TM yeast glycoproteins, Pst1 shows higher affinity for 2G12 and efficiently inhibits gp120 interactions with 2G12 and DC-SIGN, and it also blocks 2G12-mediated neutralization of HIV-1 pseudoviruses.

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