You Searched For: PROSCI INCORPORATED

Catalog Number: (10115-938)

Supplier: Prosci

Description: Polyclonal antibody Fumarase Host: Goat Target Species: human immunogen: Fumarase antibody was raised against a 14 amino acid synthetic peptide near the internal region of Fumarase. Application: ELISA, WB

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Catalog Number: (10750-782)

Supplier: Prosci

Description: SYNGR3 Antibody: Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. SYNGR3 is predominantly expressed in brain and placenta. SYNGR3 is involved in the positive regulation of dopamine transporter activity and facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release.

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Catalog Number: (10069-166)

Supplier: Prosci

Description: Monoclonal, Host: Mouse, Clone: [1131], Species Reactivity: Virus, Isotype: Mouse IgG2b, Tested Applications: IF

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Catalog Number: (10070-222)

Supplier: Prosci

Description: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

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Catalog Number: (89419-298)

Supplier: Prosci

Description: Cbl peptide is used for blocking activity of cbl antibody.

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Catalog Number: (89420-222)

Supplier: Prosci

Description: SCARA5 peptide is used for blocking the activity of SCARA5 antibody.

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Catalog Number: (10113-660)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: DAPP1 antibody was raised against a 14 amino acid synthetic peptide near the C-Terminus of DAPP1, Tested Applications: ELISA, WB

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Catalog Number: (76009-216)

Supplier: Prosci

Description: For WB starting dilution is: 1:1000

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Catalog Number: (10070-670)

Supplier: Prosci

Description: S100 calcium binding protein A1 (S100-alpha/ S100A1), The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.

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Catalog Number: (10751-414)

Supplier: Prosci

Description: SEC62 Antibody: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.

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Catalog Number: (89416-624)

Supplier: Prosci

Description: Slc22A17 Antibody: The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.

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Catalog Number: (89419-124)

Supplier: Prosci

Description: TRAF2 peptide is used for blocking the activity of TRAF2 antibody.

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Catalog Number: (10070-232)

Supplier: Prosci

Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

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Catalog Number: (89417-998)

Supplier: Prosci

Description: AFAP1 Antibody: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.

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Catalog Number: (76009-050)

Supplier: Prosci

Description: For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For FACS starting dilution is: 1:10~50

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Catalog Number: (76011-332)

Supplier: Prosci

Description: SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.

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