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Anti-ESX1 Rabbit Polyclonal Antibody

Catalog Number: (10106-562)

Supplier: Prosci

Description: ESX1 is a homeobox gene related to the mouse Esx1 homeobox gene. ESX1 is expressed during all stages of placental development and is localized to sparse areas of trophoblast in terminal villi in association with cytotrophoblastic cells. Proteolytic processing of ESX1 plays a role in concerted regulation of the cell cycle and transcription in human cells.

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Anti-IGF1R Rabbit Polyclonal Antibody

Catalog Number: (10068-954)

Supplier: Prosci

Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

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Anti-SRD5A2 Goat Polyclonal Antibody

Catalog Number: (10116-802)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Species Reactiviy: Human; Immunogen: SRD5A2 antibody was raised against a 12 amino acid synthetic peptide near the N-Terminus of SRD5A2; Application: ELISA, Western Blot

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Mouse CIDE-B Peptide (16 aa near C-terminus), ProSci

Catalog Number: (89418-480)

Supplier: Prosci

Description: CIDE-A peptide is used for blocking the activity of mCIDE-B antibody.

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Anti-LPO Goat Polyclonal Antibody

Catalog Number: (10113-104)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species: Human, Immunogen: Lactoperoxidase antibody was raised against a 13 amino acid synthetic peptide near the internal region of Lactoperoxidase, Application: ELISA, WB

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Human Recombinant FABP6 (from E. coli)

Catalog Number: (75789-118)

Supplier: Prosci

Description: Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. FABP6 plays a role in fatty acid uptake, transport, and metabolism. FABP6 stimulates gastric acid and pepsinogen secretion. It seems to be able to bind to bile salts and bilirubins.

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Human Recombinant EGFR (from Cells)

Catalog Number: (75791-710)

Supplier: Prosci

Description: The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target.

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Human Recombinant Contactin-6 (from HEK293 Cells)

Catalog Number: (75793-802)

Supplier: Prosci

Description: Contactin-6 is a member of the contactins, which mediate cell surface interactions during nervous system development. Contactin-6 has a key role in the formation of glutamatergic, but not GABAergic, synapses during postnatal development of the hippocampal formation as well as the cerebellum. It is involved in oligodendrocytes generation by acting as a ligand of Notch1. It is also involved in motor coordination.

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Human Recombinant IL17D (from E. coli)

Catalog Number: (10072-854)

Supplier: Prosci

Description: IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

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Anti-LMX1B Rabbit Polyclonal Antibody

Catalog Number: (10751-796)

Supplier: Prosci

Description: LMX1B Antibody: The LIM homeobox transcription factor 1B (LMX1B) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning; LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.

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