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Description: Polyclonal, Host: Goat, Species: Human, Immunogen: PCSK9 antibody was raised against a 14 amino acid synthetic peptide near the C-Terminus of PCSK9, Application: ELISA, WB, IHC
Catalog Number: 10112-852
Supplier: Prosci


Description: The specific function of TEX9 remains unknown.
Catalog Number: 76009-542
Supplier: Prosci


Description: The E3 ubiquitin-protein ligase MIB1, also known as Mindbomb homolog 1, contains multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. MIB1 interacts with and regulates the cellular expression of the death-associated protein kinase 1 (DAPK1) protein by promoting its ubiquitination and degradation. It also positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis.
Catalog Number: 10748-914
Supplier: Prosci


Description: MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. MTA1 was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
Catalog Number: 10106-884
Supplier: Prosci


Description: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Catalog Number: 10068-796
Supplier: Prosci


Description: Monoclonal antibody Hepatitis B Virus Host: Mouse Clone no: 1893 Species reactivity: Virus isotype: IgG1 Tested application: ELISA
Catalog Number: 10071-550
Supplier: Prosci


Description: Anti-KM871 Recombinant Antibody
Catalog Number: 76754-478
Supplier: Prosci


Description: Anti-AK8 Rabbit Polyclonal Antibody
Catalog Number: 76749-378
Supplier: Prosci


Description: NOD1 Antibody: NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
Catalog Number: 10751-054
Supplier: Prosci


Description: IRF4 Peptide
Catalog Number: 77127-504
Supplier: Prosci


Description: Anti-CD40LG Recombinant Antibody [Clone: chi220]
Catalog Number: 76630-024
Supplier: Prosci


Description: The CREB3L1 gene encodes a protein with a transmembrane domain that is a transcriptional activator of the CREB/ATF family.
Catalog Number: 10106-334
Supplier: Prosci


Description: Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
Catalog Number: 75794-478
Supplier: Prosci


Description: Anti-COPS7A Rabbit Polyclonal Antibody
Catalog Number: 76753-932
Supplier: Prosci


Description: Anti-CT-011 Recombinant Antibody
Catalog Number: 76754-806
Supplier: Prosci


Description: Anti-MSB-0010718C Recombinant Antibody
Catalog Number: 76761-636
Supplier: Prosci


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