You Searched For: Trace Measurement Limited

Catalog Number: (89360-490)

Supplier: Genetex

Description: Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).

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Catalog Number: (89279-266)

Supplier: Genetex

Description: Mouse monoclonal antibody [RB42] to RBP4

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Catalog Number: (89361-968)

Supplier: Genetex

Description: Rabbit polyclonal to Carbonic Anhydrase II

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Catalog Number: (89280-838)

Supplier: Genetex

Description: Monoclonal Antibody to NTAL/LAB Phycoerythrin (PE)

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Catalog Number: (89290-666)

Supplier: Genetex

Description: Rabbit polyclonal antibody to OR2D2

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Catalog Number: (89365-122)

Supplier: Genetex

Description: CD97, a CD55 Receptor, is a leukocyte antigen located on most activated leukocytes. CD97 is highly homologous to EMR2 with five EGF-like domains in the N-terminal extracellular domain, suggesting that it may be involved in cell signaling as well as in cell adhesion (Hamann et al., 1996). Two variants are produced by alternative splicing, where the shorter form lacks exons 5 and 6 and reduces the number of EGF-like domains from 5 to 3, compared to the full-length isoform. CD97 is associated with with the activated lesions of multiple sclerosis. CD97 expression is also implicated in the dedifferentiation of colon and thyroid tumors. CD97 is expressed abundantly in cells of hematopoietic origin and is markedly upregulated on activated T and B cells. ESTs have been isolated from a wide variety of tissue libraries.

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Catalog Number: (89354-596)

Supplier: Genetex

Description: Rabbit polyclonal antibody to ARAP1 (centaurin, delta 2)

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Catalog Number: (89270-314)

Supplier: Genetex

Description: Rabbit polyclonal antibody to RBPMS2 (Middle)

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Catalog Number: (89355-996)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to PUMA (BCL2 binding component 3)

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Catalog Number: (89298-530)

Supplier: Genetex

Description: Mouse monoclonal antibody [AT1A5] to TBCA

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Catalog Number: (89296-078)

Supplier: Genetex

Description: Goat polyclonal antibody to CRISP2

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Catalog Number: (89318-002)

Supplier: Genetex

Description: Rabbit polyclonal to Rb ( phospho S249 )

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Catalog Number: (89323-912)

Supplier: Genetex

Description: Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: WB Pkg Size: 100 ul

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Catalog Number: (89306-724)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to Id2

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Catalog Number: (89266-556)

Supplier: Genetex

Description: Rabbit polyclonal antibody to LOC51035 (Middle)

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Catalog Number: (89359-960)

Supplier: Genetex

Description: Polo-like kinases are a family of serine/threonine protein kinases, named after the prototypic founding member of the family, the polo gene product of Drosophila melanogaster. The polo kinase was originally identified in mutants that display abnormal mitotic spindle organization. Subsequently, potential homologues of Drosophila polo have been identified in yeasts (Cdc5p in Saccharomyces cerevisiae; plo1+ in Schizosaccharmoyces pombe) and in mammals (polo-like kinase 1; Plk1). Genetic and biochemical studies suggest that polo, Cdc5p and plo1+ may be required for mitotic spindle organization and, possibly, for cytokinesis. Likewise, the patterns of expression, activity and subcellular localization of Plk1 suggest that Plk12 may function during mitosis in spindle assembly and function. Recent studies have demonstrated that mammalian Plks regulate the function of the Golgi complex, a cellular organelle closely associated with the centrosome and also have microtubule organization activity. Furthermore, deregulated expression of human PLK1 and PLK3 is strongly correlated with the development of many types of malignancies, and ectopic expression of kinase-active Plk3 or Plk1 dominant negative protein leads to rapid cell death.

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