You Searched For: Van Der Voort Lucht en Milieu Amste

Supplier: Adipogen

Description: PI3Kgamma is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Kgamma IC(50) 29nM, AKT IC(50) 294nM.

Supplier: Adipogen

Description: Autofluorescent serotonin derivative. Serotonergic neurotoxin, depleting serotonin and norepinephrine. Can be used for the identification of living serotonergic neurons even in the presence of dopaminergic neurons. Its selectively uptaken into 5-hydroxytryptamine neurons. It’s oxidation products are often more potent then the parent product.

Catalog Number: (102513-408)

Supplier: Adipogen

Description: CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T cell receptor signaling.

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Supplier: Adipogen

Description: Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Potent anti-inflammatory and antihyperalgesic agent.

Supplier: Adipogen

Description: Fluorescent reagents (probe, stain, label) with reactive functional group for chromatography or spectroscopy. Derivatization agent. Used for membrane research, luminescent detection, molecular biology, protein modifications, protein structural analysis and proteomics. Carbohydrate labels for chromatography.

Supplier: Adipogen

Description: Metal-organic frameworks (MOFs).

Supplier: Adipogen

Description: A phase transfer catalyst directing enolate alkylation towards O-substitution. Starting material for preparing the corresponding fluoride, a very reactive naked fluoride, with KF.

Catalog Number: (102512-668)

Supplier: Adipogen

Description: CD8 identifies cytotoxic/suppressor T cells that interact with MHC Class I bearing targets. CD8 is thought to play a role in the process of T cell mediated killing. CD8-alpha chains binds to Class I MHC molecules alpha-3 domains. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

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Supplier: Adipogen

Description: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Supplier: Adipogen

Description: Chemiluminescent probe for the detection of peroxides in biological systems. Reagent used for the generation of chemiluminescence in the presence of a reductant and oxygen It is employed in numerous chemiluminescent assays. Lucigenin is specific for superoxide anion radical.

Catalog Number: (102514-542)

Supplier: Adipogen

Description: ANGPTL2 stimulates expansion of HSCs. ANGPTL2 plays an important role in the pathogenesis of diabetic glomerulopathy. The upregulation of ANGPTL2 in diabetic glomerulopathy shows a close relationship to abnormal microvasculature and endothelial inflammation.

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Supplier: Adipogen

Description: Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM.

Supplier: Adipogen

Description: pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively. Inhibits AMPK, DAPK3, PAK4, 5 and 6, as well as members of the AGC kinase family including PKA, PrkX and PKC isoforms (IC50 <lt/> 100 nM). Occupies the ATP binding pocket of the kinase domain and competes with ATP. Anti-cancer compound both in vitro and in vivo. Blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner, which leads to antiproliferative and apoptotic effects in tumor cell lines. Induces hyperglycemia related to peripheral insulin resistance, increased gluconeogenesis, and/or hepatic glycogenolysis.

Catalog Number: (102514-588)

Supplier: Adipogen

Description: Granulins have possible cytokine-like activity. They are important in normal development, inflammation, wound repair, and tumorigenesis.

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Catalog Number: (102514-260)

Supplier: Adipogen

Description: RIG-I (retinoic acid-inducible gene I; Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

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Catalog Number: (102514-510)

Supplier: Adipogen

Description: ANGPTL3 regulates angiogenesis and also directly regulates lipid, glucose, and energy metabolism.

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